CD-1 Mouse liver subcellular fractions
CD-1 Mouse (Mus musculus) liver subcellular fractions
The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, responsible for the maintenance of the blood sugar level and the synthesis of plasma proteins under physiological and pathophysiological conditions.
Hepatocytes are the most prominent cells within the liver. Hepatocytes eliminate toxic substances from the blood. In this biotransformation process transporter proteins (influx and efflux transporter), phase I reactions (cytochrome P450 proteins), phase II reactions (mainly glucuronidation and sulfatation) play a central role.
Subcellular liver fractions are a simple but easy to use model system to study Phase I and Phase II reactions, perfectly suited for in vitro metabolism and toxicity / detoxification studies prior to preclinical or clinical tests.