Sprague Dawley Rat Liver Cells

The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, responsible for the maintenance of the blood sugar level and the synthesis of plasma proteins under physiological and pathophysiological conditions. Cryopreserved primary liver cells are perfectly suited for in vitro metabolism and toxicity / detoxification studies prior to preclinical or clinical tests. 

Parenchymal hepatocytes are the most prominent cells within the liver. Hepatocytes eliminate toxic substances from the blood. As part of this biotransformation process, influx and efflux transporter proteins, together with phase I reactions (cytochrome P450 proteins), and phase II reactions, primarily glucuronidation and sulfation, play a central role. 

NPCs play a pivotal role during inflammatory response and fibrosis, interacting with hepatocytes and thereby complementing the liver-specific functions. Non-parenchymal liver cells, NPCs, include Kupffer cells, sinusoidal endothelial cells, and hepatic stellate cells (fat-storing cells, Ito cells). 

Rat hepatocytes and non-parenchymal liver cells are isolated and cryopreserved from livers obtained from male or female Sprague Dawley rats and are cryopreserved directly after isolation. Cryopreserved rat liver cells are used in suspension assays and plated in 2D and 3D cell cultures.

Showing 1 - 6 out of 6

Page 1 out of 1

Product Code Lot Sex Inventory (vials) Viability (%) Recovery (Viable cells/vial) plateable 24well plateable 96well 3D culture CYP1A1/1A2 induction Xfold Price (€) Quantity Action
SD-RHCP-I
male

36 in stock

86.1 +/- 1.3
> 4 Mio.
yes
yes
not tested
23.9
296,00 
SD-RHCP-I
1 male, 1 female

70 in stock

79.6
> 6 Mio.
yes
yes
not tested
23.1
495,00 
SD-RHCP-I
male, Pool of 5

56 in stock

74.9 +/- 5.6
> 6 Mio.
yes
yes
not tested
21.1
495,00 
SD-RHCP-I
female, Pool of 5

125 in stock

81.4 +/- 8.7
> 6 Mio.
yes
yes
not tested
23.0
495,00 
SD-RHCP-I
male

14 in stock

84.1
> 6 Mio.
yes
yes
not tested
16.7
495,00 
SD-RHCS
male

7 in stock

83.3 +/- 2.3
> 6 Mio.
no
no
not tested
-
399,00 

Showing 1 - 3 out of 3

Page 1 out of 1

Product Code Lot Sex Inventory (vials) Viability (%) Recovery (Viable cells/vial) Passage Price (€) Quantity Action
SD-RLKC
male

6 in stock

81.1
1.48
0
580,00 
SD-RLKC
female

10 in stock

83.9
0.94 Mio.
0
580,00 
SD-RLNPC
female

19 in stock

89.3
0.86 Mio.
0
490,00 

SD-RHCP: Sprague Dawley rat hepatocytes cryopreserved plateable

SD-RHCP-I: Sprague Dawley rat hepatocytes cryopreserved plateable, Cytochrome P450 inducible

SD-RHCP-I-3D: Sprague Dawley rat hepatocytes cryopreserved plateable, Cytochrome P450 inducible, suitable for 3D spheroid cultures

SD-RLKC: Sprague Dawley rat liver Kupffer cells cryopreserved

SD-RLNPC: Sprague Dawley rat liver nonparenchymal cells cryopreserved