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Cryopreserved Human Hepatocytes - Prequalified for Key Applications.

High quality - High Viability - Carefully characterized and validated.

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Cryopreserved Human Hepatocytes from Primacyt - Platable for use in Induction Studies

Our high quality hepatocytes are immediately usable, show high viability and perfectly match your schedules and workflow. It is a convenient solution. Start immediately with your project and do not to wait for liver tissue. Thaw and use hepatocytes where and whenever you need them.

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Cryopreserved Human Hepatocytes from Cytes.

Cytes Biotechnologies, S.L. is a biotechnology company designed to offer services based on cells isolation and cell solutions for in-vitro models addressed to the research community.

The Company is located in the Parc Científic de Barcelona, Spain. Their services comprise liver cell isolation coordination, providing scientific and technical services consisting of isolation, preservation and cellular cultivation coordination and distribution for biomedical research, including drug development, cell biology and cell therapy.

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Cryopreserved Human Hepatocytes from KaLy-Cell, platable and in Suspension

PRIMACYT partners with KaLy-Cell, a French Company based close to Strassbourg at the French-German Border. KaLy-Cell and PRIMACYT jointly serve the market for fresh and cryopreserved hepatocyte cells through their distribution networks. We offer hepatocytes in suspension or plated in a variety of formats.

KaLy-Cell is a leading Company in the field of research of in vitro metabolism, toxicity research and cell therapy. We offer cryopreserved hepatocytes in suspension and plated.

Key Application Areas Human Hepatocytes

  • Acute Cytotoxicity Assessment.Cryoheps in suspension are nearly equivalent to plated human hepatocytes (1st to 3rd treatment).
  • Prediction of Hepatic Clearance.Measurement of low metabolic compounds of cryoheps in suspension give better prediction of hepatic clearance than microsomes.
  • Prediction of Fraction Metabolized (fm) close to in vivo.CryoHeps in suspension allow evaluation of donor-specific uptake transporter inhibition and CYP inhibition.
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  • Study Donor dependent Drug Metabolism and Induction.Plateable cryopreserved hepatocytes allow the evaluation of inter-individual variations in drug metabolism enzymes (DMEs) and response to inducers.
  • Prequalified Cryoheps for specific StudiesPlateable cryopreserved hepatocytes can be obtained specically certfied for for studies of metabolism, Induction (qualified for 3 or 2 major CYPs) or certified for transporter studies.
  • Evaluation of Repeat Drug Exposure.Plateable cryopreserved hepatocytes allow the evaluation of chronic exposition to drugs by the measurement of inflammatory signals.
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Cryopreserved human hepatocytes undergo the strongest quality checks and are carefully characterized and tested. Besides the parameters as shown below, all deliveries are accompanied by additional photo documentation and other supplemental data.

Human cryopreserved hepatocytes are only for in vitro research use and not for diagnostic or therapeutic procedures.
Human cryopreserved hepatocytes should be stored in liquid nitrogen vapor (-150°C or colder). They should be thawed using Ka-Ly Cells Human CryoHep thawing kit according to the thawing protocol which are shipped with the cryopreserved hepatocytes.

All cryopreserved Human Hepatocytes are packaged to produce an Assured Minimum Yield (AMY), the minimum number of viable cells that you can expect from each vial. The AMY allows for advanced planning and budgeting for your research projects by ensuring that you get the quantity of cells needed for your specific experiment.