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Cryopreserved Cynomolgus Monkey Hepatocytes from PRIMACYT.

PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes. We offer fresh and cryopreserved animal hepatocytes in suspension and plated.

PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.
Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes in general, including related co-products, methods and tools. We are a GLP certified laboratory since 2006.




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Info Thawing and Plating Kit


Thawing and Plating Manual

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    Overview
    The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, responsible for the maintenance of the blood sugar level and the synthesis of plasma proteins under physiological and pathophysiological conditions.

    Hepatocytes are the most prominent cells within the liver. Hepatocytes eliminate toxic substances from the blood. In this biotransformation process transporter proteins (influx and efflux transporter), phase I reactions (cytochrome P450 proteins), phase II reactions (mainly glucuronidation and sulfatation) play a central role.

    Cryopreserved primary hepatocytes are ideally suited for in vitro metabolism and toxicity/detoxification studies before preclinical or clinical tests.

    Monkey hepatocytes are isolated from livers obtained from male or female Cynomolgus and are cryopreserved directly after isolation. Donor demographics stating vaccination status and health status of the animals are available for each animal. Cryopreserved Cynomolgus hepatocytes are used in suspension assays and plated in 2D and 3D cell cultures.
    Our Competencies
    PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes. We offer fresh and cryopreserved animal hepatocytes in suspension and plated.

    PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as a member of the laboratory network responsible for the method validation.

    Our colleagues are professionals and undergo continuous training in the preparation, isolation, and cryopreservation of hepatocytes in general, including related co-products, methods, and tools. We are a GLP certified laboratory since 2006.
    Our Offering
    Primacyt offers certified pools of cryopreserved Cynomolgus hepatocytes and hepatocytes from single donors. Pooled hepatocytes are obtained from three individual animal liver perfusions performed in parallel. After quality control, a pool consisting of equal numbers of viable liver cells from each donor is cryopreserved. Also, hepatocytes from individual donors are cryopreserved for reference purposes.

    Each pool and the individual single donors are comprehensively tested for viability, plate-ability, Cytochrome P450/Phase I and Phase II activities to ensure that all donors are represented equally within the pool.

    Cryopreserved hepatocytes from individual donors are also tested for drug transporter activities.
    Cynomolgus Fact Sheet
    View the three page factsheet for Cynomolgus Monkey Hepatocytes

    Additional Product Info
    This info refers to the product data below:
    • Inventory: Number of vials available as of the date of the last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post-thaw results using the thawing protocol for hepatocytes.
    • To print lot information, please select the print icon at the end of the lists below. For research use only.
    • Not intended for human or animal diagnostic or therapeutic use.
    Contact us now
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    Ask for cryopreserved Cynomolgus Monkey Hepatocyes

    Download Area (MSDS, Manuals)
    Please click on the buttons below to download MSDS data and the Plating and Thawing Manual.
    Please click on the buttons below to download MSDS data and the Plating and Thawing Manual.







    Lot and Inventory Information - Easy to order via preformatted Email or Shopping Cart.


    Product Code CHCP-I-Pool. Cryopreserved Platable Cynomolgus Hepatocytes - Certified Pool - Order Information.

    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.
    LotGenderInventoryViability %Total cells x106/vialViability %Recovery x106/vialTotal number of cells available x106CYP 1A1/2 induction x-foldPrice EUR per Vial
    CH170704-4M549410.2965.2280.88.9774.00
    Q

    Product Code CHCP-I-Pool
    Price per Vial is determined by the number of cells according to the table below:
    4 - 5.9 Mio - EUR 774.00
    6 - 9.9 Mio - EUR 1,161.00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.


    .



    Download Lot Information




    Product Code CHCP-I-T. Platable Cryopreserved Cynomolgus Monkey Hepatocytes for Use in Induction and Transporter Studies - Lot and Order Information.
    Information about CYP - Activities, Uptake and Efflux Transporter Activities are contained in the Lot-Info data, if available.


    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.

    LOTGenderInventoryViability %Total cells x106/vialViability %Recovery x106/vialTotal number of cells available x106EROD induction x-foldPrice EUR per Vial
    CH110922F179110949,7164.920.6531.00
    CH120717-2 AM68610875,834.818.9354.00
    CH121011-2M239010905,8133.413.6354.00
    CH130515-1F219210878,4176.47.7531.00
    CH130806M228710.1796,1134.210.3531.00
    CH130807F348910.2896,6224.45.0531.00
    CH131022-1M269211.2918,7226.226.0531.00
    CH131022-2M89010896,652.845.1531.00
    CH140113-2M209015.2898,0160.010.2531.00
    CH140120F59110.2845,226.020.8354.00
    Q
    This table is sortable by column. Click on the white arrows starts sorting the desired field. Click on the top left arrow resets data to thr original state.

    Product Code CHCP-I-T
    Price per Vial is determined by the number of cells according to the table below:
    2 - 3.9 Mio - EUR 177.00
    4 - 5.9 Mio - EUR 354.00
    6 - 9.9 Mio - EUR 531.00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.

    .


    Download Lot Information






    Product Code CHCP-I- Platable Cryopreserved Cynomolgus Monkey Hepatocytes for use in Induction Studies - Lot and Order Information

    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.
    LotGenderInventoryViability %Total cells x106/vialViability %Recovery x106/vialTotal number of cells available x106EROD Induction x-foldPrice EUR/Vial
    CH130515-2F1396109667818.3387.00
    CH130522M189310877.8140.44.5387.00
    CH140707M309211786.519517.3387.00
    CH140815F28810.5896.713.49.3387.00
    CH141103F119110844.852.813.9258.00
    CH141204aF209310917.014017.3387.00
    CH141204bF393158812.637.822.5387.00
    CH171009M458810.0945.424327.0258.00
    Q

    Product Code CHCP-I
    Price per Vial is determined by the number of cells according to the table below:
    2 - 3.9 Mio - EUR 129.00
    4 - 5.9 Mio - EUR 258.00
    6 - 9.9 Mio - EUR 387.00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.
    .


    Click on the Lot-Info Hyperlink to see the detailed Lot Information.
    Estron-3-Sulfate uptake data are contained in the Lot Info data Sheets.

    Download Lot Information




    Product Code CHCS: Non-characterized Cryopreserved Cynomolgus Hepatocytes for use in Suspension - Lot and Order Information
    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.
    Product Code⎟ LotGenderInventoryViability %Total cells x106/vialViability %Recovery x106/vialTotal number of cells available x106Viability after shaking for 1h at 37°CPrice EUR/Vial
    CHCS ⎟ CH110704-1M883108707. Mai6056243.00
    CHCS ⎟ CH110802-1M479108105. Mär21. Feb76162.00
    CHCS ⎟ CH110921M1884108908. Jun154.868243.00
    CHCS ⎟ CH120203-1F177108704. Jan04. Jan69162.00
    CHCS ⎟ CH120203-2F1477118745673162.00
    CHCS ⎟ CH120516-2F119210896.066.057243.00
    CHCS ⎟ CH121212-2M1994109205. Mai115.571162.00
    Q
    This table is sortable by column. Click on the column header to sort, the header will change color. Click on the top left arrow to reset data to the original state.

    Product Code CHCS
    Price per Vial is determined by the number of cells according to the table below:
    2 - 3.9 Mio - EUR 81.00
    4 - 5.9 Mio - EUR 162.00
    6 - 9.9 Mio - EUR 243.00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.

    .


    GSN-185755-I