Your Tool for Drug Discovery and Drug Development.

PRIMACYT provides subcellular liver fractions from human and a variety of animals for use in drug development in human and animal health. Also, liver cells and subcellular liver fractions are provided for environmental toxicology studies of herbicide and pesticide metabolism and bioaccumulation studies in birds and fish, like rainbow trout (Oncorhynchus mykiss) or Atlantic salmon (Salmo salar). S9 fractions and microsomes from species not listed above, e.g., turkey (Meleagris gallopavo), Mallard duck (Anas platyrhynchos) or Japanese quail (Coturnix japonica) can be made available upon request.

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Atlantic Salmon - Overview

PRIMACYT provides subcellular liver fractions from human and a variety of animals for use in drug development in human and animal health. Also, liver cells and subcellular liver fractions are provided for environmental toxicology studies of herbicide and pesticide metabolism and bioaccumulation studies in birds and fish, like rainbow trout (Oncorhynchus mykiss) or Atlantic salmon (Salmo salar). S9 fractions and microsomes from species not listed above, e.g., turkey (Meleagris gallopavo) or Mallard duck (Anas platyrhynchos) can be made available upon request. Please ask.

Further Application Fields

Subcellular fractions are suitable for a variety of experiments including

- Cytochrome P450 Inhibition Studies
- Metabolite Characterization
- Metabolic Stability
- Cytochrome P450 Phenotyping

Subcellular fractions derived from liver contain a rich variety of metabolic enzymes for assessing the in vitro metabolism of drug candidates and xenobiotics. They are used to evaluate active pharmaceutical ingredients in human and animal health. Other applications include the environmental toxicological assessment of agrochemicals and the evaluation of cosmetics and food additives.

Our Competencies

Your Primacyt Experts in Biology pertaining to the Liver

PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.

Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes in general, including related co-products, methods and tools. We are a GLP certified laboratory since 2006.

Atlantic Salmon - a new in-vitro System

More recently, researchers of the US Environmental Protection Agency (EPA), DuPont Haskell, the University of Bern and Fraunhofer IME have introduced trout hepatocytes as a reliable in-vitro system for bioaccumulation and clearances studies.

Primacyt is following this concept and introduces Atlantic Salmon as another category to allow the same studies.

The livers of the Atlantic Salmon are taken from non-sexually mature animals. The salmon were kept under controlled conditions, based on the OECD Guideline 319A / B. So posture and isolation condition follow this directive.

Literature

In progress

Our Offering

in Progress

Additional Product Info

This info refers to the product data below:

Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
Viability: Denotes post thaw results using the thawing protocol for fish hepatocytes.
To print lot information, please select the print icon at the end of the lists below.
For research use only. Not intended for human or animal diagnostic or therapeutic use.

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Download Area MSDS

Please click on the buttons below to download MSDS data and the Plating and Thawing Manual.

MSDS Material Data Sheet: ALS