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Key Points to consider for Cryopreserved Hepatocytes

Cryopreserved hepatocytes can be stored for years at predefined conditions in the vapor phase of liquid nitrogen or in freezers at temperatures below -135°C. Available when you need them, they are an ideal solution for sequential experiments over time.

Combine cryopreserved hepatocytes from your choice of donors. Create and define your preferred hepatic metabolism system in suspensions or on culture plates for extended studies, such as for multiple or gradient toxicity and metabolism experiments.

Cryopreserved hepatocytes in suspension are typically used for studies related to drug metabolism and systems biology.. Experiments should not exceed four to six hours.
Not always are fresh hepatocytes available on demand. Hepatocytes, cryopreserved at the day of isolation may be an alternative choice to fresh hepatocytes. Cryoheps allow quick access to specific donor characteristics and desired quantities.

Cryopreserved hepatocytes are available extremely well characterized.
Our high quality hepatocytes are immediately usable, show high viability and perfectly match your schedules and workflow. It is a convenient solution. Start immediately with your project and do not to wait for liver tissue. Thaw and use hepatocytes where and whenever you need them.

Identify your compounds earlier and win by more efficient and fasters preclinical projects. You can delegate time and intense cell isolations to us as your partner to gain capacity and speed for your of your core R&D activities.

Key Application Areas Human Hepatocytes

Primary Hepatocytes are best suited to demonstrate major tissue functions, such as ammonia detoxification or drug metabolism. Hepatocytes act as a living biological system. Cryopreserved hepatocytes are extremely well characterised and qualified for key applications.
  • Acute Cytotoxicity Assessment.Cryoheps in suspension are nearly equivalent to plated human hepatocytes (1st to 3rd treatment).
  • Prediction of Hepatic Clearance.Measurement of low metabolic compounds of cryoheps in suspension give better prediction of hepatic clearance than microsomes.
  • Prediction of Fraction Metabolized (fm) close to in vivo.CryoHeps in suspension allow evaluation of donor-specific uptake transporter inhibition and CYP inhibition.
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  • Study Donor dependent Drug Metabolism and Induction.Plateable cryopreserved hepatocytes allow the evaluation of inter-individual variations in drug metabolism enzymes (DMEs) and response to inducers.
  • Prequalified Cryoheps for specific StudiesPlateable cryopreserved hepatocytes can be obtained specically certfied for for studies of metabolism, Induction (qualified for 3 or 2 major CYPs) or certified for transporter studies.
  • Evaluation of Repeat Drug Exposure.Plateable cryopreserved hepatocytes allow the evaluation of chronic exposition to drugs by the measurement of inflammatory signals.
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