<
Stacks Image 1977004




Cryopreserved Rat Hepatocytes from PRIMACYT.

PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading Company in the field of research of human and animal hepatocytes. We offer fresh and cryopreserved animal hepatocytes in suspension and plated.

Primacyt provides primary rat hepatocytes and non-parenchymal liver cells for 2D and 3D cell cultures. They mimic hepatocellular functions.

Primary hepatocytes are
perfect models for in vitro metabolism and toxicity studies. They are essential before clinical in vivo assessments and for bioaccumulation and clearance studies,

The liver fulfills many vital processes in the body for energy metabolisms, such as glycolysis, gluconeogenesis, lipid, and amino acid metabolisms.

Under physiological and pathophysiological conditions, the liver is responsible for the maintenance of the blood sugar level and the synthesis of plasma proteins, ammonia detoxification (ureagenesis), and drug metabolism.

Parenchymal hepatocytes are the most prominent cells within the liver. Hepatocytes eliminate toxic substances from the blood. As part of this biotransformation process, influx and efflux transporter proteins, together with phase I reactions (cytochrome P450 proteins), and phase II reactions, primarily glucuronidation and sulfation, play a central role.

NPCs play a pivotal role during inflammatory response and fibrosis, interacting with hepatocytes and thereby complementing the liver-specific functions. Non-parenchymal liver cells, NPCs, include Kupffer cells, endothelial cells, and fat-storing cells, such as Ito cells, hepatic stellate cells).


Primacyt provides primary rat hepatocytes and non-parenchymal liver cells for 2D and 3D cell cultures. They mimic hepatocellular functions.

Primary hepatocytes are
perfect models for in vitro metabolism and toxicity studies. They are essential before clinical in vivo assessments and for bioaccumulation and clearance studies,

The liver fulfills many vital processes in the body for energy metabolisms, such as glycolysis, gluconeogenesis, lipid, and amino acid metabolisms.

Under physiological and pathophysiological conditions, the liver is responsible for the maintenance of the blood sugar level and the synthesis of plasma proteins, ammonia detoxification (ureagenesis), and drug metabolism.


Parenchymal hepatocytes are the most prominent cells within the liver. Hepatocytes eliminate toxic substances from the blood. As part of this biotransformation process, influx and efflux transporter proteins, together with phase I reactions (cytochrome P450 proteins), and phase II reactions, primarily glucuronidation and sulfation, play a central role.

NPCs play a pivotal role during inflammatory response and fibrosis, interacting with hepatocytes and thereby complementing the liver-specific functions. Non-parenchymal liver cells, NPCs, include Kupffer cells, endothelial cells, and fat-storing cells, such as Ito cells, hepatic stellate cells).


PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.
Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes in general, including related co-products, methods and tools. We are a GLP certified laboratory since 2006.
PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.

Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes in general, including related co-products, methods and tools. We are a GLP certified laboratory since 2006.




Wistar: Han

Product Code WH-RHCP-I. Rat Hepatocytes Cryopreserved Plateable for Induction Studies - Lot and Order Information

  • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
  • Viability: Denotes post thaw results using the standard thawing protocol.
  • To print lot information, please select print icon at the end of this list.

-200629

Lot / Gender

Inventory (Number of vials)

Viability (%)

Recovery (Number of viable cells/vial)

Total number of cells available

CYP1A1/1A2 induction x-fold

EUR / Vial

RH190417 Male

3

92.6

> 6 Mio

> 18 Mio

16.0

256.50

RH190424 Male

5

84.7

> 6 Mio

> 156 Mio

30.2

256.50

RH190514 Female

34

84.6

> 6 Mio

> 204 Mio

16.0

256.50

RH190813 Female

32

86.9

> 6 Mio

> 192 Mio

21.8

256.50

Q

Quantity:


Download Lot Information



Sprague Dawley

Product Code SD-RHCP-I. Rat Hepatocytes Cryopreserved Plateable for Induction Studies - Lot and Order Information

  • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
  • Viability: Denotes post thaw results using the standard thawing protocol.
  • To print lot information, please select print icon at the end of this list.

-200629

Lot / Gender

Inventory (Number of vials)

Viability (%)

Recovery (Number of viable cells/vial)

Total number of cells available

CYP1A1/1A2 induction x-fold

EUR / Vial

RH191007 Male

44

87.3 +/- 0.0

> 4 Mio

> 176 Mio

21.9

171.00

RH191112 Pool Mixed

70

79.6 +/-0.0

> 6 Mio

> 420 Mio

23.1

256.50

RH191205 Pool 5 Male

158

74.9 +/-5.6

> 6 Mio

> 948 Mio

21.1

256.50

RH200226-1 Pool 5 Female

172

81.4 +/-8.7

> 6 Mio

> 1032 Mio

23.0

256.50

Q

Quantity:


Download Lot Information