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PRIMACYT Subcellular Fractions - Suffolk Sheep (Ovies Aries)

Your Tool for Drug Discovery and Drug Development.




PRIMACYT provides subcellular liver fractions from human and a variety of animals for use in drug development in human and animal health. Also, liver cells and subcellular liver fractions are provided for environmental toxicology studies of herbicide and pesticide metabolism and bioaccumulation studies in birds and fish, like rainbow trout (Oncorhynchus mykiss) or Atlantic salmon (Salmo salar). S9 fractions and microsomes from species not listed above, e.g., turkey (Meleagris gallopavo), Mallard duck (Anas platyrhynchos) or Japanese quail (Coturnix japonica) can be made available upon request. Please ask.

Subcellular fractions derived from liver contain a rich variety of metabolic enzymes for assessing the in vitro metabolism of drug candidates and xenobiotics. They are used to evaluate active pharmaceutical ingredients in human and animal health. Other applications include the environmental toxicological assessment of agrochemicals and the evaluation of cosmetics and food additives.
Precinical studies require the understandíng the potenial interaction between novel candidates and other drugs including information about the underlying pathways. The liver is predominant for the metabolism for endogenous compounds and xenobiotics. Enzymes contained in the Cytochrome P450 superfamily of the liver are used predominantly in invitro drug biotransformation studies.

Read the corresponding review from the University of Stellenbosch.

Application Fields

Subcellular fractions are suitable for a variety of experiments including

- Cytochrome P450 Inhibition Studies
- Metabolite Characterization
- Metabolic Stability
- Cytochrome P450 Phenotyping

Your Primacyt Experts in Biology pertaining to the Liver.
PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.

Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes and other related cells. We are a GLP certified laboratory since 2006.

Did you know?
The subcellular distribution of the zearalenone-reducing activity in liver from goat is special. Comparing pig, goat, sheep, cow and hen the goat has been identified together whith pig had the greatest ability to form alpha- and beta-zearalenol in the microsomal fraction independently of coenzyme.
Read the publication from the NIH.

For research use only. Not intended for human or animal diagnostic or therapeutic use.
Product Codes SL-S9-201 / SL MIC-201
  A B C D E F G H I J
1 Inventory Information Product Data
2 Product No. Product Lot No. Gender Specification Characteristics Protein content (mg/ml) Unit Size (ml) Packaging Euro per vial
3 SL-S9-201 Sheep Liver S9 fraction Sheep150727 female single donor CYP metabolism / SDS PAGE 20 1 vial 27.80
4 SL-MIC-201 Sheep Liver Microsomes Shepp150727 female single donor CYP metabolism / SDS PAGE 20 1 vial 58.80
5 Publishing Date November 30, 2016

Product Codes SL-S9 and SL-MIC

Quantity:


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